Description

Fidaxomicin D7 CAS NO 2143934-06-7 is a deuterium-labeled analog of the macrocyclic antibiotic fidaxomicin, serving as a critical internal standard for precise quantitative analysis. This high-purity, stable isotope-labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in advanced drug development and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS quantification of fidaxomicin and its metabolites in biological matrices (plasma, serum, urine).
• Bioanalytical method development and validation in support of clinical trials and preclinical studies.
• Metabolic stability and pharmacokinetic (PK/ADME) research to understand drug disposition.
• Use in high-resolution mass spectrometry (HRMS) for definitive metabolite identification and structural elucidation.
• Quality control and assurance in the manufacturing of fidaxomicin-based pharmaceutical products.
• Reference material for regulatory submissions to agencies like the FDA and EMA.

Basic Information

Product Name	Fidaxomicin D7
CAS No.	2143934-06-7
Molecular Formula	C52H67D7ClO18
Molecular Weight	~1058.6 g/mol
Synonyms	Fidaxomicin-d7; Tiacumicin B-d7; OPT-80-d7; PAR-101-d7; Difimicin-d7; Lipiarmycin A3-d7; (3R,4aR,5'R,6S,6'S,7R,10S,11aR,13S,14aR,15'S,16aR,17R,18S,19aS)-6'-{[(2S,3S,4S,5S,6R)-4-Amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-17-[(2R,3S,4S,5S,6S)-3,4-dihydroxy-6-methyl-5-{[(2R,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]-5',7,10,11a,15',16a,17,18-octahydro-3,6,9,16-tetramethyl-14a-{[(1R)-1-methylpropyl]oxy}spiro[2H,13H-oxireno[2,3-e]pyrano[4',3':4,5]furo[3,2-c][1,7,10]benzotrioxacyclooctadecine-13,2'-oxane]-4,8,15,19(1H,3H,19aH)-tetrone-d7
EINECS	Contact for details

Quality Control

Our Fidaxomicin D7 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced spectroscopic and chromatographic analyses, including NMR, HPLC, and MS. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your sensitive assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the product should be handled under anhydrous conditions and allowed to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.