Description

(R)-1-(1H-Indazol-4-Yl)-n-(2,2,2-Trifluoroethyl)Propan-2-Amine is a high-purity chiral amine building block of significant interest in advanced pharmaceutical research and development. Its value lies in its unique molecular architecture, combining an indazole heterocycle with a trifluoroethylamine moiety, which is crucial for modulating the biological activity and pharmacokinetic properties of drug candidates. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic agents, particularly in areas targeting central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Preclinical Development: Employed in the synthesis of compounds for pharmacological profiling and toxicology studies.
• Process Chemistry: Acts as a starting material or intermediate in the development of scalable synthetic routes for candidate drugs.
• Bioconjugation & Probe Development: Potential use in creating chemical probes for biochemical and cellular target validation.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in enantioselective synthesis.

Basic Information

Product Name	(R)-1-(1H-Indazol-4-Yl)-n-(2,2,2-Trifluoroethyl)Propan-2-Amine
CAS No.	2142634-00-0
Molecular Formula	C₁₄H₁₆F₃N₃
Molecular Weight	283.29 g/mol
Synonyms	(R)-1-(1H-Indazol-4-yl)-N-(2,2,2-trifluoroethyl)propan-2-amine; (2R)-1-(1H-Indazol-4-yl)-N-(2,2,2-trifluoroethyl)propan-2-amine; (R)-1-(1H-Indazol-4-yl)-N-(2,2,2-trifluoroethyl)-2-propylamine; UNII-9J4F3W6A4I; 9J4F3W6A4I; (R)-N-(2,2,2-Trifluoroethyl)-1-(1H-indazol-4-yl)propan-2-amine; (R)-1-(1H-Indazol-4-yl)-N-(trifluoroethyl)isopropylamine
EINECS	Contact for details

Quality Control

Our (R)-1-(1H-Indazol-4-Yl)-n-(2,2,2-Trifluoroethyl)Propan-2-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.