Description

Propanoic Acid, 3-[2-[[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-4-Yl]Amino]Ethoxy]-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex therapeutic agents. This compound is critical for research and development in targeted drug discovery, particularly in the field of oncology and immunology. It is an essential building block for medicinal chemists and pharmaceutical manufacturers requiring precise molecular scaffolds for the development of Proteolysis Targeting Chimeras (PROTACs) and other novel modalities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drugs and targeted protein degraders (e.g., PROTACs).
• Oncology Research: Used in the development of experimental cancer therapeutics targeting specific cellular pathways.
• Medicinal Chemistry: Serves as a sophisticated building block for structure-activity relationship (SAR) studies and lead optimization.
• Bioconjugation: Potential use in creating antibody-drug conjugates (ADCs) due to its functionalized linker structure.
• Process Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under cGMP conditions.
• Academic & Contract Research: Utilized in university and CRO laboratories for cutting-edge drug discovery projects.

Basic Information

Product Name	Propanoic Acid, 3-[2-[[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-4-Yl]Amino]Ethoxy]-, 1,1-Dimethylethyl Ester
CAS No.	2140807-19-6
Molecular Formula	C24H29N3O8
Molecular Weight	487.51 g/mol
Synonyms	tert-Butyl 3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoate; PROTAC Linker; E3 Ligase Ligand-Linker Conjugate; Lenalidomide-based Linker; Cereblon Ligand Linker; (S,R,S)-AHPC-C4-O-C2-NH-PEG2-CH2CH2COOtBu; 3-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid tert-butyl ester
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality management systems. Each batch is subjected to rigorous analytical testing including HPLC for purity and identity confirmation by NMR and MS. We provide comprehensive Certificates of Analysis (COA) with full traceability. Our manufacturing aligns with ISO 9001 standards, and we support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.