Description

5,6-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, fluorinated heterocyclic building block of significant interest in modern pharmaceutical research and development. Its core value lies in its utility as a key synthetic intermediate for creating novel bioactive molecules, particularly in the discovery of central nervous system (CNS) and oncology therapeutics. This compound is essential for medicinal chemists and R&D departments in pharmaceutical, biotechnology, and fine chemical synthesis companies seeking to develop new drug candidates with optimized properties.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in CNS and oncology research pipelines.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluorinated tetrahydroisoquinoline scaffold.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study biological targets and pathways.
• Advanced Fine Chemical Synthesis: Used in multi-step synthetic routes for complex, high-value organic molecules.
• Agrochemical Research: Potential intermediate in the development of new active ingredients with enhanced efficacy.

Basic Information

Item	Detail
Product Name	5,6-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	2138522-82-2
Molecular Formula	C9H9F2N•HCl
Molecular Weight	205.63 g/mol (Free base: 169.17 g/mol)
Synonyms	5,6-Difluoro-1,2,3,4-tetrahydroisoquinoline HCl; 5,6-Difluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride; 5,6-Difluoro-3,4-dihydro-1H-isoquinoline hydrochloride; 1,2,3,4-Tetrahydro-5,6-difluoroisoquinoline hydrochloride; 5,6-Difluoro-THIQ HCl; DF-THIQ HCl
EINECS	Contact for details

Quality Control

Our 5,6-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring research and development-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.