Description

6-Bromo-Benzoic-2,3,4,5-D4 Acid is a deuterium-labeled derivative of 6-bromobenzoic acid, serving as a critical stable isotope-labeled internal standard and building block. Its primary value lies in enabling precise quantitative analysis and metabolic pathway tracing in complex biological and chemical matrices using mass spectrometry. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors who require reliable, isotopically pure materials for method development and regulatory compliance.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a quantitative reference standard in bioanalytical methods for drug metabolism and pharmacokinetics (DMPK) studies.
• Pharmaceutical Research & Development: A key deuterated synthon for the preparation of isotopically labeled drug candidates, aiding in metabolic stability and mechanism of action studies.
• Metabolomics and Biomarker Discovery: Facilitates accurate quantification of benzoic acid derivatives and related metabolites in complex biological samples.
• Agrochemical Research: Employed in the development and environmental fate studies of new active ingredients.
• Material Science: Used as a precursor for synthesizing deuterated polymers or liquid crystals for specialized optical and electronic applications.
• Forensic and Environmental Analysis: Acts as a tracer in method development for detecting related compounds in environmental or forensic samples.

Basic Information

Product Name	6-Bromo-Benzoic-2,3,4,5-D4 Acid
CAS No.	2133385-73-4
Molecular Formula	C7D4HBrO2
Molecular Weight	201.04 g/mol (approx.)
Synonyms	6-Bromo-2,3,4,5-tetradeuterobenzoic Acid; 6-Bromobenzoic-2,3,4,5-d4 Acid; 2,3,4,5-Tetradeutero-6-bromobenzoic Acid; 6-Bromobenzoic Acid-d4; Benzoic-2,3,4,5-d4 Acid, 6-Bromo-; (2,3,4,5-Tetradeuterophenyl)-6-bromocarboxylic Acid
EINECS	Contact for details

Quality Control

Our 6-Bromo-Benzoic-2,3,4,5-D4 Acid is manufactured under strict quality systems to ensure isotopic and chemical purity suitable for sensitive analytical applications. Each batch is characterized by NMR (1H, 13C) and mass spectrometry to confirm deuteration level and identity, with purity typically determined by HPLC. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and related substances are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.