Description

n-Mal-n-Bis(Peg2-Nh-Boc) is a specialized heterobifunctional crosslinking reagent featuring a maleimide group and two Boc-protected amine-terminated polyethylene glycol (PEG) arms. This compound is engineered to provide controlled, site-specific conjugation in advanced bioconjugation and pharmaceutical development workflows. It is primarily utilized by researchers and process developers in the fields of biopharmaceuticals, antibody-drug conjugate (ADC) development, and proteomics to create stable, well-defined linkages between biomolecules and other functional entities.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Enables the controlled attachment of cytotoxic payloads to antibodies via thiol-maleimide chemistry, with the PEG spacer enhancing solubility and pharmacokinetics.
• Protein and Peptide Modification: Used for site-specific labeling, PEGylation, or functionalization of cysteine-containing proteins and peptides.
• Surface Immobilization and Bioconjugation: Facilitates the creation of functionalized surfaces for biosensors, microarrays, and diagnostic assays by linking biomolecules to solid supports.
• Polymer and Dendrimer Synthesis: Serves as a key building block for constructing complex, multi-functional polymeric architectures with cleavable or modifiable sites.
• Prodrug Development: Employed in designing prodrugs where the Boc-protected amine allows for triggered release of the active pharmaceutical ingredient under specific physiological conditions.
• Research and Development: A critical tool in academic and industrial R&D for exploring novel drug delivery systems and biomaterial interfaces.

Basic Information

Item	Detail
Product Name	n-Mal-n-Bis(Peg2-Nh-Boc)
CAS No.	2128735-26-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1,1'-(2,2'-(2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethylazanediyl)bis(ethane-2,1-diyl))bis(oxy)bis(N-(tert-butoxycarbonyl)ethane-2,1-diamine); Maleimide-PEG2-Boc Amine; Boc-NH-PEG2-Maleimide; Heterobifunctional PEG Crosslinker, Maleimide and Boc-amine; N-(2-(2-(2-(Boc-amino)ethoxy)ethoxy)ethyl)maleimide derivative; CAS 2128735-26-0
EINECS	Contact for details

Quality Control

Every batch of n-Mal-n-Bis(Peg2-Nh-Boc) is subjected to rigorous analytical testing to ensure identity, purity, and consistency suitable for research and development applications. Our quality management system supports traceability and compliance. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC/NMR), identity confirmation, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. Use under an inert atmosphere for critical applications.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.