Description

1-Chloronaphthalene-4-Boronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its value lies in its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in pharmaceutical R&D, agrochemical discovery, and materials science, particularly for developing novel active ingredients and functional organic materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, especially those containing complex naphthalene-based scaffolds.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a stable boronic ester partner in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds, a cornerstone of modern medicinal chemistry.
• Agrochemical Synthesis: Employed in the research and development of new herbicides, fungicides, and insecticides that require specific chloronaphthalene motifs.
• Organic Light-Emitting Diodes (OLEDs): Serves as a precursor for creating novel organic semiconductors and emissive materials used in display and lighting technologies.
• Ligand and Catalyst Development: Useful for constructing sophisticated ligand frameworks for catalysis and molecular recognition applications.
• Material Science Research: A key monomer or precursor for developing advanced polymers, liquid crystals, and other functional organic materials.

Basic Information

Product Name	1-Chloronaphthalene-4-Boronic Acid, Pinacol Ester
CAS No.	2128285-49-2
Molecular Formula	C₁₆H₁₈BClO₂
Molecular Weight	288.58 g/mol
Synonyms	4-Chloro-1-naphthaleneboronic acid pinacol ester; 1-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalene; (4-Chloronaphthalen-1-yl)boronic acid pinacol ester; Pinacol (4-chloro-1-naphthyl)boronate; 1-Chloro-4-naphthaleneboronic acid pinacol ester; CAS 2128285-49-2; 4,4,5,5-Tetramethyl-2-(4-chloronaphthalen-1-yl)-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 1-Chloronaphthalene-4-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with relevant regulatory frameworks for advanced intermediates in target industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.