Description

Endo-Bcn-Peg8-Acid CAS NO 2126805-02-3 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring an endo-BCN (bicyclo[6.1.0]nonyne) group and a terminal carboxylic acid. This compound is engineered for precision bioconjugation, enabling efficient, catalyst-free click chemistry reactions with azide-functionalized molecules under mild, biocompatible conditions. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, proteomics, and advanced materials science, facilitating the creation of stable, well-defined conjugates for therapeutics, diagnostics, and biomaterials.

Application

• ADC (Antibody-Drug Conjugate) Development: As a hydrophilic spacer to link cytotoxic payloads to monoclonal antibodies, improving solubility and pharmacokinetics.
• Protein and Peptide Modification: For site-specific PEGylation to enhance stability, reduce immunogenicity, and prolong circulation half-life of biologic drugs.
• Fluorescent Probe and Diagnostic Agent Conjugation: Creating imaging agents for in vitro and in vivo diagnostics via stable triazole linkages.
• Surface Functionalization and Biomaterial Engineering: Modifying nanoparticles, hydrogels, or sensor surfaces with bioactive ligands for targeted delivery or sensing applications.
• Chemical Biology and Proteomics: As a tool for labeling, pull-down assays, and studying biomolecular interactions using bioorthogonal chemistry.
• Polymer and Dendrimer Synthesis: Serving as a building block for constructing complex, multifunctional macromolecular architectures.

Basic Information

Product Name	Endo-Bcn-Peg8-Acid
CAS No.	2126805-02-3
Molecular Formula	C41H73NO18
Molecular Weight	868.0 g/mol (Contact for exact value)
Synonyms	endo-BCN-PEG8-acid; endo-BCN-PEG8-COOH; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (1-amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-yl)carbamate; 1-(1,3-Dioxoisoindolin-2-yl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid BCN ester; BCN-PEG8-Acid; Azadibenzocyclooctyne-PEG8-Acid; ADIBO-PEG8-acid; DBCO-PEG8-acid (Note: BCN is a regioisomer of DBCO)
EINECS	Contact for details

Quality Control

Our Endo-Bcn-Peg8-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, water, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.