Description

Quinagolide-D10 is a high-purity, deuterium-labeled analog of the dopamine agonist quinagolide, specifically designed for use as an internal standard in advanced analytical applications. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry, particularly in pharmacokinetic and metabolic studies. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise and traceable analytical methods.

Application

• Used as a deuterated internal standard for the precise quantification of quinagolide in biological matrices (e.g., plasma, serum, tissue) via LC-MS/MS.
• Facilitates drug metabolism and pharmacokinetics (DMPK) studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of quinagolide.
• Enables bioanalytical method development and validation in compliance with regulatory guidelines (e.g., FDA, EMA) for clinical trial sample analysis.
• Supports pharmaceutical quality control and stability testing by providing a reference for impurity profiling and assay determination.
• Applied in academic and industrial research investigating dopaminergic pathways, prolactin inhibition, and related endocrine disorders.
• Essential for forensic and toxicological analysis where accurate identification and quantification of the parent drug are required.

Basic Information

Product Name	Quinagolide-D10
CAS No.	2124271-76-5
Molecular Formula	C20H18D10N4O
Molecular Weight	~334.5 g/mol
Synonyms	Norprolac-D10; CV 205-502-D10; (3-allyl-6,6a,7,8,9,10,10a,11-octahydro-7-[2H10]propyl-7H-pyrido[4,3-g]quinolin-2-yl)guanidine; Quinagolide (deuterated, D10); Quinagolide-d10; Deuterated Quinagolide Internal Standard
EINECS	Contact for details

Quality Control

Our Quinagolide-D10 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity (by HPLC), and confirmation of structure (by NMR and MS). We support cGMP and ISO 9001 compliant workflows, and specifications can be tailored to meet specific pharmacopeial or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98.0 atom % D
Chemical Purity (by 1H NMR)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.