Description

5-(T-Butyldimethylsilyloxymethyl)Thiophen-3-Boronic Acid is a high-value organoboron building block, specifically a protected thiophene boronic acid derivative, essential for modern synthetic chemistry. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules in pharmaceutical and advanced materials research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in constructing heterocyclic cores prevalent in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific thiophene-based architectures.
• Material Science & Organic Electronics: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds between the thiophene ring and various aryl or heteroaryl halides.
• Custom Synthesis & Contract Research: Supplied to CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic projects.

Basic Information

Product Name	5-(T-Butyldimethylsilyloxymethyl)Thiophen-3-Boronic Acid
CAS No.	2122282-85-1
Molecular Formula	C11H21BO3SSi
Molecular Weight	272.26 g/mol
Synonyms	5-[(tert-Butyldimethylsilyloxy)methyl]thiophene-3-boronic acid; 3-Borono-5-[(tert-butyldimethylsilyloxy)methyl]thiophene; 5-((tert-Butyldimethylsilyloxy)methyl)thiophene-3-boronic acid; TBDMS-Protected Thiophene-3-Boronic Acid; 3-Thiopheneboronic acid, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-; 5-(TBDMS-oxymethyl)thiophen-3-ylboronic acid
EINECS	Contact for details

Quality Control

Our 5-(T-Butyldimethylsilyloxymethyl)Thiophen-3-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.