Description

4-Benzyloxy-2-Chloropyrimidine-5-Boronic Acid is a high-purity boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation, which is essential for constructing complex molecular architectures. This compound is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a versatile boronic acid coupling partner for constructing biaryl and heterobiaryl systems central to many drug molecules.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific pyrimidine-based structures.
• Material Science: Employed in the creation of organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Serves as a valuable tool compound for studying biological pathways and developing biochemical probes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and libraries for client projects.

Basic Information

Product Name	4-Benzyloxy-2-Chloropyrimidine-5-Boronic Acid
CAS No.	2121513-94-6
Molecular Formula	C11H10BClN2O3
Molecular Weight	264.47 g/mol
Synonyms	2-Chloro-4-(phenylmethoxy)-5-pyrimidineboronic acid; (2-Chloro-4-(benzyloxy)pyrimidin-5-yl)boronic acid; 4-(Benzyloxy)-2-chloro-5-pyrimidineboronic acid; 5-Borono-4-benzyloxy-2-chloropyrimidine; 2-Chloro-4-benzyloxypyrimidine-5-boronic acid; B-[2-Chloro-4-(phenylmethoxy)-5-pyrimidinyl]boronic acid
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-2-Chloropyrimidine-5-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.