Description

2-Chloro-6-Fluoro-3-Methoxyphenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic organic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl halides and this boronic ester, crucial for synthesizing biaryl structures found in many pharmaceuticals.
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly those requiring the specific 2-chloro-6-fluoro-3-methoxyphenyl moiety.
• Agrochemical Synthesis: Serves as a precursor in creating advanced herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or conductive polymers, where precise molecular structure is paramount.
• Chemical Biology & Probe Development: Useful for creating tagged molecules or affinity probes to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scaled-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	2-Chloro-6-Fluoro-3-Methoxyphenylboronic Acid Pinacol Ester
CAS No.	2121512-16-9
Molecular Formula	C13H17BClFO3
Molecular Weight	285.54 g/mol
Synonyms	2-Chloro-6-fluoro-3-methoxyphenylboronic acid pinacol ester; (2-Chloro-6-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Chloro-6-fluoro-3-methoxybenzeneboronic acid pinacol ester; Pinacol (2-chloro-6-fluoro-3-methoxyphenyl)boronate; 2-(2-Chloro-6-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; B-(2-Chloro-6-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 2121512-16-9
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-Fluoro-3-Methoxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes comprehensive analysis via NMR (¹H, ¹³C, ¹¹B), HPLC, and GC to meet the exacting requirements of research and process chemistry. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom purity grades or analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.