Description

3-Formylthiophene-4-Boronic Acid Pincol Ester is a high-value, multifunctional heterocyclic building block designed for advanced organic synthesis. This compound matters because it combines a reactive formyl group with a protected boronic acid moiety, enabling precise cross-coupling reactions and subsequent functionalization in a single molecule. Pharmaceutical, agrochemical, and material science R&D teams need it for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs), organic electronic materials, and novel catalysts.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl and heterobiaryl compounds, essential for drug discovery.
• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential therapeutic agents, especially those containing thiophene scaffolds.
• Material Science & Organic Electronics: Used in the development of conjugated polymers and small molecules for organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Agrochemical Research: Employed in creating novel active ingredients for crop protection products.
• Ligand & Catalyst Development: The thiophene and boronate ester functionalities make it useful for designing novel ligands for transition metal catalysis.
• Chemical Biology & Probe Synthesis: Useful for creating molecular probes and bioconjugates due to its orthogonal reactive sites.

Basic Information

Product Name	3-Formylthiophene-4-Boronic Acid Pincol Ester
CAS No.	2121511-75-7
Molecular Formula	C11H15BO3S
Molecular Weight	238.11 g/mol
Synonyms	4-Formyl-3-thiopheneboronic acid pinacol ester; 3-Formyl-4-thienylboronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxaldehyde; 3-Thiophenecarboxaldehyde, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 3-Formyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene; 4-(Pinacolatoboryl)thiophene-3-carboxaldehyde; 3-Formyl-4-boronothiophene pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Formylthiophene-4-Boronic Acid Pincol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.