Description

(2S)-2-(2,5-Dioxo-3-Propylpyrrolidin-1-Yl)Butanoic Acid is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic utility. Its core value lies in its role as a key precursor for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the synthesis of complex molecules, including potential protease inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new chemical entities (NCEs) and Active Pharmaceutical Ingredients (APIs).
• Protease Inhibitor Synthesis: Serves as a key building block in the synthetic pathways for targeted protease inhibitors.
• Peptidomimetic Chemistry: Used in the design and construction of peptidomimetics and constrained peptide analogs to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed in stereoselective synthesis due to its defined (2S) configuration, enabling the construction of complex chiral centers.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Bioconjugation Chemistry: Potential use in linker chemistry for antibody-drug conjugates (ADCs) or other targeted delivery systems, leveraging its functional groups.

Basic Information

Product Name	(2S)-2-(2,5-Dioxo-3-Propylpyrrolidin-1-Yl)Butanoic Acid
CAS No.	2101641-92-1
Molecular Formula	C11H17NO4
Molecular Weight	227.26 g/mol
Synonyms	(S)-2-(2,5-Dioxo-3-propylpyrrolidin-1-yl)butanoic acid; (2S)-2-(2,5-Dioxo-3-propyl-1-pyrrolidinyl)butanoic Acid; L-2-(2,5-Dioxo-3-propylpyrrolidin-1-yl)butyric Acid; 1-(1-Carboxypropyl)-3-propyl-2,5-pyrrolidinedione; 2101641-92-1; Butanoic acid, 2-(2,5-dioxo-3-propyl-1-pyrrolidinyl)-, (2S)-
EINECS	Contact for details

Quality Control

Our (2S)-2-(2,5-Dioxo-3-Propylpyrrolidin-1-Yl)Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with stringent specifications for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.