Description

[3-(4-Bromophenyl)-2,2-Difluorocyclopropyl]Methanol is a high-value, multi-functional fluorinated cyclopropane derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a bromophenyl group and a difluorocyclopropane ring, makes it indispensable for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the difluorocyclopropane unit can contribute to improved activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of novel fluorinated polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes to study biological systems and enzyme mechanisms.
• Custom Synthesis and Scale-up: A vital starting material for contract research and manufacturing organizations (CROs/CMOs) engaged in custom synthesis projects from milligram to kilogram scale.

Basic Information

Product Name	[3-(4-Bromophenyl)-2,2-Difluorocyclopropyl]Methanol
CAS No.	2098118-22-8
Molecular Formula	C10H9BrF2O
Molecular Weight	263.08 g/mol
Synonyms	(3-(4-Bromophenyl)-2,2-difluorocyclopropyl)methanol; 1-(4-Bromophenyl)-2,2-difluoro-3-(hydroxymethyl)cyclopropane; 2,2-Difluoro-3-(hydroxymethyl)-1-(4-bromophenyl)cyclopropane; 4-Bromo-α-(2,2-difluorocyclopropyl)benzenemethanol; [3-(p-Bromophenyl)-2,2-difluorocyclopropyl]methanol
EINECS	Contact for details

Quality Control

Every batch of [3-(4-Bromophenyl)-2,2-Difluorocyclopropyl]Methanol is produced and tested under strict quality management protocols to ensure consistency and purity for research and development applications. Our products undergo rigorous analytical testing, including chiral purity analysis, to meet the exacting standards of the fine chemical industry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.