Description

Carbamic Acid, n-[2-[2-[2-[[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-4-Yl]Amino]Ethoxy]Ethoxy]Ethyl]-, 1,1-Dimethylethyl Ester is a sophisticated, high-purity chemical intermediate designed for advanced pharmaceutical synthesis. This compound is critical for researchers and manufacturers developing next-generation targeted therapies, particularly in oncology. Its complex structure, featuring a phthalimide and piperidinyl dioxo core linked by a polyethylene glycol (PEG)-based spacer, makes it an essential building block for Proteolysis Targeting Chimeras (PROTACs) and other bifunctional molecules. Sourcing this material from a reliable supplier is paramount for ensuring the integrity and success of complex drug discovery and development pipelines.

Application

• Key Intermediate in PROTAC Synthesis: Serves as a critical linker-warhead conjugate for constructing novel Proteolysis Targeting Chimeras (PROTACs) aimed at degrading disease-causing proteins.
• Pharmaceutical Research & Development: Used in the discovery and preclinical development of targeted cancer therapies and other small-molecule drugs.
• Bioconjugation and ADC Development: The reactive amine and ester groups facilitate its use in bioconjugation strategies for creating antibody-drug conjugates (ADCs) or other targeted delivery systems.
• Chemical Biology Tool: Employed in academic and industrial research to study protein-protein interactions and intracellular degradation pathways.
• Synthesis of Cereblon (CRBN) E3 Ligase Binders: The phthalimide moiety is a known ligand for the CRBN E3 ubiquitin ligase, making this compound vital for designing CRBN-recruiting therapeutic molecules.
• High-Value Fine Chemical Production: Manufactured under strict GMP-like conditions for use in cGMP-compliant drug substance synthesis.

Basic Information

Product Name	Carbamic Acid, n-[2-[2-[2-[[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-4-Yl]Amino]Ethoxy]Ethoxy]Ethyl]-, 1,1-Dimethylethyl Ester
CAS No.	2097509-40-3
Molecular Formula	C28H38N4O10
Molecular Weight	590.63 g/mol
Synonyms	tert-Butyl N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]carbamate; PROTAC Linker 17; CRBN Ligand-Linker Conjugate 17; (S,R,S)-AHPC-PEG3-C2-NH-Boc; E3 Ligase Ligand-Linker Conjugate 12; (S)-tert-Butyl (2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)carbamate; Boc-PEG3-C2-CRBN ligand
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality management systems, ensuring batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and LC-MS to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications such as assay purity, chiral purity, and residual solvent levels. We support development and commercial projects with quality standards suitable for cGMP manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C ± 5°C. This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.