Description

2-Chloro-6-[(4-Methoxyphenyl)Methoxy]-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, advanced pharmaceutical intermediate featuring a pyridine core functionalized with both a chlorinated aryl ether and a pinacol boronate ester. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel drug candidates and active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key boron-containing partner for palladium-catalyzed C-C bond formation with aryl/heteroaryl halides.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Agrochemical Synthesis: Serves as a precursor for developing novel herbicides, fungicides, and insecticides.
• Material Science Research: A building block for creating organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the development of molecular probes and diagnostic agents.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for commercial manufacturing processes.

Basic Information

Product Name	2-Chloro-6-[(4-Methoxyphenyl)Methoxy]-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	2096331-22-3
Molecular Formula	C19H23BClNO4
Molecular Weight	375.65 g/mol
Synonyms	2-Chloro-6-[(4-methoxyphenyl)methoxy]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-6-[(4-methoxyphenyl)methoxy]pyridine; 2-Chloro-6-(4-methoxybenzyloxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol ester of [2-Chloro-6-((4-methoxybenzyl)oxy)pyridin-4-yl]boronic acid; B-[2-Chloro-6-[(4-methoxyphenyl)methoxy]-4-pyridinyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-[(4-Methoxyphenyl)Methoxy]-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.