Description

(3S)-7-Fluoro-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic A is a high-purity, chiral tetrahydroisoquinoline carboxylic acid derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its specific stereochemistry and fluorine substitution, which are essential for modulating the biological activity and metabolic stability of target drug candidates. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs).
• Drug Discovery & Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Protease Inhibitor Development: The carboxylic acid and tetrahydroisoquinoline scaffold are common motifs in the design of enzyme inhibitors.
• Chemical Biology Research: Employed as a molecular probe or precursor for studying biological pathways and protein interactions.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective chemical transformations.
• Preclinical Research: Serves as a critical material for pharmacokinetic and toxicology studies during early-stage drug development.

Basic Information

Product Name	(3S)-7-Fluoro-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic A
CAS No.	2095676-47-2
Molecular Formula	C10H10FNO2
Molecular Weight	195.19 g/mol
Synonyms	(3S)-7-Fluoro-3,4-dihydro-1H-isoquinoline-3-carboxylic acid; 7-Fluoro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, (3S)-; (S)-7-Fluoro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (3S)-7-Fluoro-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; 7-Fluoro-D-Tic-OH; F-D-Tic-OH; (S)-7-Fluoro-Tic-OH
EINECS	Contact for details

Quality Control

Our (3S)-7-Fluoro-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic A is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.