Description

4-Chloro-6-(difluoromethyl)thieno[3,2-d]pyrimidine is a high-purity, advanced pharmaceutical intermediate belonging to the thienopyrimidine class of heterocyclic compounds. This compound is a critical building block in modern medicinal chemistry, valued for its unique molecular scaffold that enables the synthesis of targeted bioactive molecules. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and antiviral drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic substitutions, and other transformations to construct complex molecular architectures.
• Agrochemical Research: Serves as an intermediate in the synthesis of novel crop protection agents and herbicides.
• Material Science: Investigated for potential use in the development of organic electronic materials due to its fused heterocyclic structure.

Basic Information

Product Name	4-Chloro-6-(difluoromethyl)thieno[3,2-d]pyrimidine
CAS No.	2092627-98-8
Molecular Formula	C7H3ClF2N2S
Molecular Weight	220.62 g/mol
Synonyms	4-Chloro-6-(difluoromethyl)thieno[3,2-d]pyrimidine; Thieno[3,2-d]pyrimidine, 4-chloro-6-(difluoromethyl)-; 6-(Difluoromethyl)-4-chlorothieno[3,2-d]pyrimidine; 4-Chloro-6-difluoromethyl-thieno[3,2-d]pyrimidine; 2092627-98-8
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-6-(difluoromethyl)thieno[3,2-d]pyrimidine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets a typical purity specification of ≥97% (by HPLC), with detailed impurity profiling available. A Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.