Description

5-[trans-2-{[(tert-Butoxy)Carbonyl]Amino}Cyclopropyl]Thiophene-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclopropyl-thiophene scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing novel bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of potential drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical space.
• Protease Inhibitor Scaffold: The molecular architecture is suitable for developing inhibitors of various protease enzymes, a common drug target class.
• Kinase Inhibitor Precursor: Serves as a core structure or side-chain component in the design of potential kinase inhibitor therapeutics.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	5-[trans-2-{[(tert-Butoxy)Carbonyl]Amino}Cyclopropyl]Thiophene-2-Carboxylic Acid
CAS No.	2092435-93-1
Molecular Formula	C13H17NO4S
Molecular Weight	283.34 g/mol
Synonyms	5-[(trans-2-{[(tert-Butoxy)carbonyl]amino}cyclopropyl)]thiophene-2-carboxylic acid; 2-Thiophenecarboxylic acid, 5-[trans-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopropyl]-; Boc-ACPC-thiophene-2-carboxylic acid; (trans)-N-Boc-2-(2-Carboxythiophen-5-yl)cyclopropylamine; tert-Butyl (trans-2-(5-carboxythiophen-2-yl)cyclopropyl)carbamate; 5-((trans)-2-((tert-Butoxycarbonyl)amino)cyclopropyl)thiophene-2-carboxylic Acid; CAS 2092435-93-1
EINECS	Contact for details

Quality Control

Our 5-[trans-2-{[(tert-Butoxy)Carbonyl]Amino}Cyclopropyl]Thiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for every lot. The product is available in standard research grades and can be supplied under more stringent quality protocols, including cGMP standards, for advanced development and manufacturing purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.