Description

4-Fluoroindoline-5-Carbonitrile is a high-value fluorinated indoline derivative, serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the creation of novel pharmacophores with enhanced biological activity and metabolic stability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the synthesis of new-generation herbicides and pesticides, where the fluorine atom can improve lipophilicity and target binding.
• Material Science Precursor: Acts as a starting material for synthesizing functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	4-Fluoroindoline-5-Carbonitrile
CAS No.	2092093-82-6
Molecular Formula	C9H7FN2
Molecular Weight	162.16 g/mol
Synonyms	5-Cyano-4-fluoroindoline; 4-Fluoro-2,3-dihydro-1H-indole-5-carbonitrile; 4-Fluoroindoline-5-carbonitrile; 1H-Indole-5-carbonitrile, 4-fluoro-2,3-dihydro-; 4-Fluoro-2,3-dihydroindole-5-carbonitrile
EINECS	Contact for details

Quality Control

Our 4-Fluoroindoline-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.