Description

3-Bromo-2-Chloro-5-(Difluoromethyl)Thiophene is a high-value, multi-functionalized heterocyclic building block. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique halogen and difluoromethyl pattern enables precise molecular modifications. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate complex thiophene motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides with enhanced activity and environmental profiles.
• Material Science: Serves as a precursor for functionalized polymers, organic semiconductors, and liquid crystals.
• Chemical Research (R&D): A versatile scaffold for medicinal chemistry and discovery chemistry programs exploring structure-activity relationships (SAR).
• Ligand and Catalyst Development: Useful for constructing complex ligands used in transition metal catalysis.
• Fluorine Chemistry: The difluoromethyl group makes it a valuable substrate for further fluorination reactions and metabolic stability studies.

Basic Information

Product Name	3-Bromo-2-Chloro-5-(Difluoromethyl)Thiophene
CAS No.	2091608-75-0
Molecular Formula	C5H2BrClF2S
Molecular Weight	247.49 g/mol
Synonyms	2-Chloro-3-bromo-5-(difluoromethyl)thiophene; 5-(Difluoromethyl)-3-bromo-2-chlorothiophene; Thiophene, 3-bromo-2-chloro-5-(difluoromethyl)-; 3-Bromo-2-chloro-5-difluoromethylthiophene
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Chloro-5-(Difluoromethyl)Thiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/GC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.