Description

Pyridine, 6-Fluoro-2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional boronic ester derivative of a substituted pyridine, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who are developing novel active ingredients and functional organic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated heterocyclic structures.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed coupling with aryl/heteroaryl halides, enabling efficient carbon-carbon bond formation.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and labeled compounds for diagnostic and research applications.
• Ligand Synthesis for Catalysis: Acts as a starting material for the preparation of sophisticated nitrogen-containing ligands used in asymmetric catalysis.

Basic Information

Product Name	Pyridine, 6-Fluoro-2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	2085307-49-7
Molecular Formula	C14H19BFNO3
Molecular Weight	279.12 g/mol
Synonyms	6-Fluoro-2-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Boronic acid, 6-fluoro-2-methoxypyridine-, pinacol ester; (6-Fluoro-2-methoxypyridin-3-yl)boronic acid pinacol ester; 2-Methoxy-6-fluoro-3-pyridineboronic acid pinacol ester; 6-Fluoro-2-methoxy-3-pyridineboronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-fluoro-2-methoxypyridine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for assay, related substances, and residual solvents are available upon request. We adhere to strict quality management protocols suitable for cGMP and ISO environments to support our customers' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as specified on the label. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent hydrolysis of the boronic ester. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥95.0%
Related Substances (HPLC)	Individual impurity ≤1.0%; Total impurities ≤3.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.