Description

1-(Benzyloxy)-4-Bromo-6-Chloro-2-(Trifluoromethyl)Benzene is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines bromo, chloro, and trifluoromethyl substituents on a benzyloxy-protected benzene core, enabling precise chemical modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the trifluoromethyl and halogen groups.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorine Chemistry Building Block: The stable trifluoromethyl group provides a source of fluorine for designing compounds with enhanced metabolic stability, lipophilicity, and bioavailability.
• Chemical Biology Probe Development: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a tagged molecule in biochemical assays.

Basic Information

Product Name	1-(Benzyloxy)-4-Bromo-6-Chloro-2-(Trifluoromethyl)Benzene
CAS No.	2070896-27-2
Molecular Formula	C14H9BrClF3O
Molecular Weight	380.57 g/mol
Synonyms	4-Bromo-6-chloro-2-(trifluoromethyl) phenyl benzyl ether; 1-Benzyloxy-4-bromo-6-chloro-2-(trifluoromethyl)benzene; Benzene, 1-(benzyloxy)-4-bromo-6-chloro-2-(trifluoromethyl)-; 4-Bromo-6-chloro-2-trifluoromethyl phenyl benzyl ether; 2-(Trifluoromethyl)-4-bromo-6-chlorophenyl benzyl ether
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of 1-(Benzyloxy)-4-Bromo-6-Chloro-2-(Trifluoromethyl)Benzene is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing all critical parameters are available upon request. Our quality management system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids/bases and oxidizing agents. For long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.