Description

Trimethobenzamide-D6 is a high-purity, stable isotope-labeled internal standard essential for precise quantitative analysis. This deuterated compound is critical for ensuring accuracy and reliability in advanced analytical methodologies, particularly in regulated environments. It is primarily required by pharmaceutical research, contract research organizations (CROs), and analytical laboratories for applications in drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Internal standard for the accurate quantification of Trimethobenzamide in biological matrices using LC-MS/MS and GC-MS.
• Critical reagent in pharmaceutical research and development for drug metabolism and pharmacokinetic (DMPK) studies.
• Use in bioanalytical method development and validation to meet FDA and EMA regulatory guidelines.
• Essential for clinical and pre-clinical trial sample analysis to ensure data integrity.
• Application in forensic toxicology for the precise detection and measurement of antiemetic drugs.
• Used in environmental fate studies of pharmaceutical compounds.
• Supporting material for the synthesis of other labeled metabolites or derivatives.

Basic Information

Product Name	Trimethobenzamide-D6
CAS No.	2070014-97-8
Molecular Formula	C21H20D6N3O2
Molecular Weight	354.48 g/mol
Synonyms	Trimethobenzamide-d6; Tigan-d6; 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2,6-dimethoxybenzamide-d6; Benzamide-d6, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2,6-dimethoxy-; Deuterated Trimethobenzamide; Trimethobenzamide (hexadeuterated); Trimethobenzamide Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Trimethobenzamide-D6 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and mass spectrometry for structural confirmation and deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and solvent residue levels to support your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.