Description

Ivabradine (D6 Hydrochloride) is a deuterated isotopologue of the selective sinus node If channel inhibitor Ivabradine, where six hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemists working on the development, validation, and regulatory submission of Ivabradine-based therapies.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise measurement of Ivabradine in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track and quantify the parent drug and its metabolites.
• Clinical Trial Support: Enables accurate bioanalysis for therapeutic drug monitoring and pharmacokinetic profiling during clinical trials of Ivabradine.
• Pharmaceutical Quality Control: Supports method development and validation for impurity profiling and assay of Ivabradine in active pharmaceutical ingredient (API) and finished dosage forms.
• Stable Isotope Tracing: Facilitates mechanistic studies in preclinical research to elucidate metabolic pathways using deuterium as a tracer.
• Reference Material: Serves as a high-purity certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity in regulated laboratories.

Basic Information

Product Name	Ivabradine (D6 Hydrochloride)
CAS No.	2070009-63-9
Molecular Formula	C27H37D6N2O5•HCl
Molecular Weight	~ 541.13 g/mol
Synonyms	Ivabradine-d6 hydrochloride; S 16257-d6; Procoralan-d6 (labeled); (3-{3-[({[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one)-d6 hydrochloride; 2H-Ivabradine hydrochloride; Ivabradine (hexadeuterated) hydrochloride
EINECS	Contact for details

Quality Control

Our stable isotope-labeled materials are produced under strict quality management systems. Each batch of Ivabradine (D6 Hydrochloride) undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C) and High-Resolution Mass Spectrometry (HRMS) to confirm structure and isotopic enrichment, and HPLC for chemical and isotopic purity assessment. Certificates of Analysis (COA) detailing all specifications are provided and traceable to primary standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Isotopic Purity (HPLC-MS)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.