Description

Sodium:(E,3R,5S)-7-[4-(4-Fluorophenyl)-6-(1,1,1,3,3,3-Hexadeuteriopropan-2-Yl)-2-[Methyl(Methylsulfonyl)Amino]Pyrimidin-5-Yl]-3,5-Dihydroxyhept-6-Enoate is a high-purity, deuterated sodium salt of a statin-like pharmacophore, designed for advanced pharmaceutical research and development. This compound is critical for metabolic pathway studies, offering enhanced stability and traceability in pharmacokinetic and pharmacodynamic analyses due to its deuterium-labeled side chain. It is primarily utilized by pharmaceutical companies and research institutions engaged in the development of novel HMG-CoA reductase inhibitors and lipid-lowering therapeutics.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control and method validation in the production of deuterated active pharmaceutical ingredients (APIs).
• Metabolic Research: Used as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS assays for accurate quantification of parent drugs and metabolites in biological matrices.
• Drug Discovery & Development: A key intermediate or building block in the synthesis of next-generation deuterated statin analogs aimed at improving metabolic stability and patent life.
• Clinical Trial Support: Employed in mass spectrometry imaging (MSI) and other advanced analytical techniques to study drug distribution and mechanism of action in preclinical models.
• Regulatory Submissions: Provides essential data for Investigational New Drug (IND) and New Drug Application (NDA) filings to demonstrate analytical method specificity and sensitivity.

Basic Information

Item	Details
Product Name	Sodium:(E,3R,5S)-7-[4-(4-Fluorophenyl)-6-(1,1,1,3,3,3-Hexadeuteriopropan-2-Yl)-2-[Methyl(Methylsulfonyl)Amino]Pyrimidin-5-Yl]-3,5-Dihydroxyhept-6-Enoate
CAS No.	2070009-41-3
Molecular Formula	C28H33D6FN3NaO7S
Molecular Weight	Approx. 621.7 g/mol (Contact for details)
Synonyms	Sodium Pitavastatin-d6 Derivative; Deuterated Pitavastatin Sodium Salt; (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1,1,1,3,3,3-Hexadeuterio-2-propan-2-yl)-2-(N-methylmethanesulfonamido)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic Acid Sodium Salt; Livalo-d6 Sodium Salt; NK-104-d6 Sodium Salt; Sodium (E)-7-[4-(4-Fluorophenyl)-6-[(1,1,1,3,3,3-Hexadeuterio)propan-2-yl]-2-(methylsulfonylmethylamino)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
EINECS	Contact for details

Quality Control

Our Sodium:(E,3R,5S)-7-[4-(4-Fluorophenyl)-6-(1,1,1,3,3,3-Hexadeuteriopropan-2-Yl)-2-[Methyl(Methylsulfonyl)Amino]Pyrimidin-5-Yl]-3,5-Dihydroxyhept-6-Enoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chemical and isotopic purity, NMR for structural confirmation, and MS for identity verification, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.