Description

Naltrexone-D4 CAS NO 2070009-29-7 is a deuterated analog of naltrexone, a well-known opioid antagonist. This stable isotope-labeled compound is essential for advanced analytical research, providing a critical internal standard for precise and accurate quantification in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, forensic toxicology units, and clinical research organizations engaged in pharmacokinetic studies, drug metabolism research, and high-sensitivity bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the quantification of naltrexone and its metabolites in plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical trials.
• Forensic and Clinical Toxicology: Used in confirmatory testing and method development for the accurate detection of opioid antagonists in forensic and diagnostic settings.
• Drug Metabolism Research (DMPK): Facilitates the identification and quantification of metabolite profiles, aiding in the understanding of metabolic pathways.
• Pharmaceutical Quality Control: Applied in the validation of analytical methods for drug substance and drug product testing within GMP environments.
• Reference Material for Certified Standards: Acts as a high-purity starting material for the preparation of certified reference materials (CRMs).

Basic Information

Product Name	Naltrexone-D4
CAS No.	2070009-29-7
Molecular Formula	C20H19D4NO4
Molecular Weight	345.43 g/mol
Synonyms	Naltrexone-d4; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one-d4; (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one-d4; Naltrexone (phenyl-d4); LCI-1024; EN-1639A; UM-792; CPH-101; Norrex-d4; Opioid Antagonist-d4
EINECS	Contact for details

Quality Control

Our Naltrexone-D4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on assay, impurities, and residual solvents. Our quality commitment ensures the material meets the stringent requirements for use as an analytical reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. After opening, seal the container tightly under an inert atmosphere such as argon or nitrogen to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.