Description

5-Amino-2-[(2-Methylpropan-2-Yl)Oxycarbonyl]-3,4-Dihydro-1H-Isoquinoline-8-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing fused isoquinoline scaffolds, enabling structure-activity relationship (SAR) studies.
• Research & Development (R&D): Essential for academic and industrial R&D labs exploring new chemical entities and novel synthetic pathways.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial APIs under GMP conditions.
• Protease Inhibitor Research: The structural motif suggests potential utility in the development of protease enzyme inhibitors for various therapeutic applications.

Basic Information

Product Name	5-Amino-2-[(2-Methylpropan-2-Yl)Oxycarbonyl]-3,4-Dihydro-1H-Isoquinoline-8-Carboxylic Acid
CAS No.	2060031-16-3
Molecular Formula	C15H18N2O4
Molecular Weight	290.32 g/mol
Synonyms	5-Amino-2-(tert-butoxycarbonyl)-3,4-dihydro-1H-isoquinoline-8-carboxylic acid; 8-Carboxy-5-amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 5-Amino-2-Boc-1,2,3,4-tetrahydroisoquinoline-8-carboxylic acid; 2-(tert-Butoxycarbonyl)-5-amino-3,4-dihydro-1H-isoquinoline-8-carboxylic acid; 5-Amino-2-Boc-1,2,3,4-tetrahydroisoquinoline-8-COOH; Boc-5-Amino-Tic-OH derivative; tert-Butyl 5-amino-8-carboxy-3,4-dihydro-1H-isoquinoline-2(1H)-carboxylate
EINECS	Contact for details

Quality Control

Our production of 5-Amino-2-[(2-Methylpropan-2-Yl)Oxycarbonyl]-3,4-Dihydro-1H-Isoquinoline-8-Carboxylic Acid adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.