Description

2(1H)-Isoquinolinecarboxylic Acid, 5-Amino-8-Bromo-3,4-Dihydro-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated and amino-substituted isoquinoline structure. This compound is of significant value in medicinal chemistry for the synthesis of novel drug candidates, particularly those targeting complex biological pathways. It is primarily required by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential therapeutic agents, especially in oncology and central nervous system (CNS) drug discovery.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its reactive amino and bromo functional groups.
• Organic Synthesis: Serves as a versatile precursor for further chemical modifications, including cross-coupling reactions, amide bond formation, and ester hydrolysis.
• Biochemical Tool Compound: Potential use in the development of biochemical probes and inhibitors for enzymatic assays and target validation.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals for advanced applications.

Basic Information

Product Name	2(1H)-Isoquinolinecarboxylic Acid, 5-Amino-8-Bromo-3,4-Dihydro-, 1,1-Dimethylethyl Ester
CAS No.	2059944-11-3
Molecular Formula	C15H19BrN2O2
Molecular Weight	339.23 g/mol
Synonyms	5-Amino-8-bromo-3,4-dihydro-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 5-amino-8-bromo-3,4-dihydro-1H-isoquinoline-2-carboxylate; 8-Bromo-5-amino-3,4-dihydro-2(1H)-isoquinolinecarboxylic acid tert-butyl ester; 5-Amino-8-bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 5-amino-8-bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; CAS 2059944-11-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.