Description

Isoquinoline, 1-[(4S)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]- is a high-purity, chiral chemical building block featuring a fused isoquinoline-oxazoline scaffold. This compound is of significant value for pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and chiral ligands. It serves as a critical intermediate for medicinal chemists and process development scientists working in asymmetric synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and oncology targets.
• Asymmetric Catalysis: Serves as a precursor for the synthesis of novel chiral ligands and catalysts used in enantioselective transformations.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its privileged isoquinoline structure.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential APIs under Good Manufacturing Practice (GMP) guidelines.
• Academic & Industrial R&D: A valuable reagent for investigating new synthetic methodologies and heterocyclic chemistry in laboratory settings.

Basic Information

Product Name	Isoquinoline, 1-[(4S)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]-
CAS No.	2058236-52-3
Molecular Formula	C19H18N2O
Molecular Weight	290.36 g/mol
Synonyms	(4S)-4-(Benzyl)-4,5-dihydro-2-(isoquinolin-1-yl)oxazole; 1-[(4S)-4-Benzyl-4,5-dihydro-1,3-oxazol-2-yl]isoquinoline; (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole; (S)-1-(4-Benzyl-4,5-dihydrooxazol-2-yl)isoquinoline; 1-[(4S)-4,5-Dihydro-4-(phenylmethyl)-2-oxazolyl]isoquinoline; Chiral Isoquinoline-Oxazoline Ligand Precursor
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles. We employ analytical techniques including HPLC, GC, NMR, and chiral analysis to meet the exacting standards required for pharmaceutical R&D. Specifications can be aligned with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.