Description

2-Chloro-5-Fluoro-3-(Trifluoromethyl)Benzyl Alcohol is a high-value, multi-functional fluorinated aromatic building block. This compound is critical for introducing a trifluoromethyl-substituted benzyl alcohol moiety into complex molecular architectures, significantly altering physicochemical properties. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its unique halogen and fluorine pattern is leveraged to enhance metabolic stability, lipophilicity, and binding affinity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved stability and performance.
• Polymer & Resin Modifier: Incorporated to create specialty polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: A versatile reagent for Suzuki, Sonogashira, and other cross-coupling reactions to construct complex aromatic systems.
• Chemical Research & Development: Essential for medicinal chemistry programs and material science exploring structure-activity relationships (SAR).

Basic Information

Product Name	2-Chloro-5-Fluoro-3-(Trifluoromethyl)Benzyl Alcohol
CAS No.	2056110-51-9
Molecular Formula	C8H5ClF4O
Molecular Weight	228.57 g/mol
Synonyms	(2-Chloro-5-fluoro-3-(trifluoromethyl)phenyl)methanol; 1-(Chloro-5-fluoro-3-(trifluoromethyl)phenyl)methanol; 2-Chloro-5-fluoro-α,α,α-trifluoro-m-tolyl alcohol; 2-Chloro-5-fluoro-3-trifluoromethylbenzyl alcohol; 2-Chloro-5-fluoro-α,α,α-trifluoro-m-tolylcarbinol; Benzyl alcohol, 2-chloro-5-fluoro-3-(trifluoromethyl)-; (2-Chloro-5-fluoro-3-(trifluoromethyl)phenyl)carbinol
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-3-(Trifluoromethyl)Benzyl Alcohol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber glass, or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.