Description

5-[(1S,2S)-Rel-2-Aminocyclopropyl]Thiophene-2-Carboxylic Acid Hydrochloride is a high-purity chiral building block of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a key synthetic intermediate in the creation of novel, biologically active molecules, particularly in medicinal chemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potential drug candidates, especially in protease inhibitor and kinase inhibitor research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its constrained cyclopropyl and thiophene motifs.
• Peptidomimetic Development: Serves as a scaffold for designing and synthesizing peptidomimetics and other bioactive compounds.
• Agrochemical Synthesis: Potential intermediate in the development of new active ingredients for crop protection.
• Chemical Biology Probes: Utilized in the creation of tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects and scale-up activities.

Basic Information

Product Name	5-[(1S,2S)-Rel-2-Aminocyclopropyl]Thiophene-2-Carboxylic Acid Hydrochloride
CAS No.	2055841-95-5
Molecular Formula	C8H10ClNO2S
Molecular Weight	219.69 g/mol
Synonyms	5-[(1S,2S)-2-Aminocyclopropyl]thiophene-2-carboxylic acid hydrochloride; (1S,2S)-2-(5-Carboxythiophen-2-yl)cyclopropan-1-amine hydrochloride; 2-Thiophenecarboxylic acid, 5-[(1S,2S)-2-aminocyclopropyl]-, hydrochloride; rel-(1S,2S)-2-(5-Carboxy-2-thienyl)cyclopropanamine hydrochloride; 5-(2-Aminocyclopropyl)thiophene-2-carboxylic acid hydrochloride (rel-(1S,2S)-isomer); CAS 2055841-95-5
EINECS	Contact for details

Quality Control

Our 5-[(1S,2S)-Rel-2-Aminocyclopropyl]Thiophene-2-Carboxylic Acid Hydrochloride is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity, suitable for demanding research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.