Description

2-Azaspiro[3.3]Heptane-6-Carboxylic Acid, Methyl Ester, 2,2,2-Trifluoroacetate (1:1) is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and trifluoroacetate-protected amine structure. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, pain management, and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space due to its constrained spirocyclic scaffold.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the scale-up and optimization of synthetic routes for candidate drugs.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential use as a component in the linker or ligand design for bifunctional degrader molecules.
• Agrochemical Research: Exploration of novel bioactive compounds for crop protection, leveraging the physicochemical properties imparted by the fluorine atoms and rigid structure.
• Chemical Biology Probes: Incorporation into molecular probes for studying enzyme function or protein-protein interactions within biological systems.

Basic Information

Product Name	2-Azaspiro[3.3]Heptane-6-Carboxylic Acid, Methyl Ester, 2,2,2-Trifluoroacetate (1:1)
CAS No.	2055497-44-2
Molecular Formula	C10H12F3NO4
Molecular Weight	267.20 g/mol
Synonyms	Methyl 2-azaspiro[3.3]heptane-6-carboxylate 2,2,2-trifluoroacetate; 2-Azaspiro[3.3]heptane-6-carboxylic acid methyl ester trifluoroacetate salt; 6-(Methoxycarbonyl)-2-azaspiro[3.3]heptane 2,2,2-trifluoroacetate; Methyl 6-azaspiro[2.4]heptane-1-carboxylate trifluoroacetate (alternative numbering); 2-N-Boc-2-azaspiro[3.3]heptane-6-carboxylic acid methyl ester TFA salt (common precursor name); Spiro[3.3]heptane-6-methyl carboxylate, 2-aza-, TFA salt
EINECS	Contact for details

Quality Control

Our production of 2-Azaspiro[3.3]Heptane-6-Carboxylic Acid, Methyl Ester, 2,2,2-Trifluoroacetate (1:1) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.