Description

4-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-5-(Trifluoromethyl)-1H-Indazole CAS NO 2044704-81-4 is a high-purity, advanced pharmaceutical intermediate featuring a strategically functionalized indazole core. This compound is specifically engineered to serve as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of small molecule drugs, particularly within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies due to its versatile bromo and trifluoromethyl substituents.
• Oncology Drug Discovery: Serves as a core scaffold for developing potential kinase inhibitors and other anticancer agents.
• CNS Drug Development: Employed in the research of neuroactive compounds, leveraging the indazole pharmacophore.
• Agrochemical Research: Potential intermediate for developing new generation herbicides or fungicides with enhanced activity.
• Material Science: Can be investigated as a monomer or functional additive for specialty polymers with unique electronic or optical properties.

Basic Information

Product Name	4-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-5-(Trifluoromethyl)-1H-Indazole
CAS No.	2044704-81-4
Molecular Formula	C13H12BrF3N2O
Molecular Weight	349.15 g/mol
Synonyms	4-Bromo-1-(tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-1H-indazole; 1H-Indazole, 4-bromo-1-(tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-; 4-Bromo-1-THP-5-trifluoromethyl-1H-indazole; 4-Bromo-1-(THP)-5-(CF3)-1H-indazole; 4-Br-1-THP-5-CF3-1H-indazole; 2044704-81-4; 4-Bromo-1-(tetrahydropyran-2-yl)-5-(trifluoromethyl)indazole
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-5-(Trifluoromethyl)-1H-Indazole is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity required for sensitive research and development applications. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.