Description

tert-Butyl 2-(Hydroxymethyl)-4-Methyl-1H-Indole-1-Carboxylate is a high-purity, protected indole derivative serving as a critical advanced intermediate in modern organic synthesis. This compound matters because it provides a versatile and reactive scaffold for constructing complex molecules, offering chemists a handle for selective functionalization. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, particularly in medicinal chemistry programs targeting novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those with indole-based pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its reactive hydroxymethyl and protected carboxylate groups.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, or plant growth regulators.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized fine chemicals.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 2-(Hydroxymethyl)-4-Methyl-1H-Indole-1-Carboxylate
CAS No.	2044704-80-3
Molecular Formula	C15H19NO3
Molecular Weight	261.32 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 2-(hydroxymethyl)-4-methyl-, 1,1-dimethylethyl ester; 2-(Hydroxymethyl)-4-methyl-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 2-(hydroxymethyl)-4-methylindole-1-carboxylate; Boc-2-(hydroxymethyl)-4-methylindole; 4-Methyl-2-hydroxymethylindole N-Boc protected; N-Boc-2-(hydroxymethyl)-4-methylindole; 2044704-80-3
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Hydroxymethyl)-4-Methyl-1H-Indole-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.