Description

1-(Tetrahydro-2H-Pyran-2-Yl)-5-(Trifluoromethyl)-1H-Indazol-4-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique indazole core protected by a tetrahydropyran (THP) group. This compound matters for its critical role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical R&D teams and fine chemical manufacturers need it to develop next-generation drug candidates, especially in oncology and central nervous system (CNS) research, where its structural motifs are highly valuable.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug molecules and investigational new drugs (INDs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Development: Integral in the development route for potential Active Pharmaceutical Ingredients (APIs), particularly those targeting kinase inhibition or receptor modulation.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.
• Agrochemical Research: Potential application as an intermediate in the development of novel agrochemicals with specific biological activity.

Basic Information

Product Name	1-(Tetrahydro-2H-Pyran-2-Yl)-5-(Trifluoromethyl)-1H-Indazol-4-Amine
CAS No.	2044703-06-0
Molecular Formula	C13H14F3N3O
Molecular Weight	285.27 g/mol
Synonyms	4-Amino-1-(tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-1H-indazole; 5-(Trifluoromethyl)-1-(tetrahydropyran-2-yl)-1H-indazol-4-amine; 1H-Indazol-4-amine, 1-(tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-; THP-protected 5-trifluoromethylindazol-4-amine; CAS 2044703-06-0
EINECS	Contact for details

Quality Control

Our 1-(Tetrahydro-2H-Pyran-2-Yl)-5-(Trifluoromethyl)-1H-Indazol-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets exacting standards for research and development use. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.