Description

Piperazine, 1-(Methyl-D3)-, Hydrochloride (1:2) is a deuterated derivative of piperazine, a versatile heterocyclic amine, where three hydrogen atoms on the methyl group are replaced by deuterium. This isotopic labeling is critical for applications requiring precise molecular tracking and analysis, offering enhanced stability and distinct spectroscopic properties. It is an essential building block and analytical standard for researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors, particularly for drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Pharmaceutical Research & Development: Used as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of piperazine-based drugs and their metabolites.
• Drug Metabolism Studies (DMPK): Essential for tracing the absorption, distribution, metabolism, and excretion (ADME) pathways of candidate drugs, leveraging deuterium's kinetic isotope effect.
• Synthetic Chemistry Intermediate: Serves as a specialized building block for the synthesis of deuterium-labeled analogs of active pharmaceutical ingredients (APIs) and other fine chemicals.
• Analytical Reference Standard: Provides a high-purity certified reference material (CRM) for method development, validation, and quality control in analytical laboratories.
• Agrochemical Research: Employed in the development and analysis of deuterated agrochemicals to study environmental fate and metabolic pathways.
• NMR Spectroscopy: Acts as a useful probe in nuclear magnetic resonance (NMR) spectroscopy due to the distinct magnetic properties of deuterium.

Basic Information

Item	Detail
Product Name	Piperazine, 1-(Methyl-D3)-, Hydrochloride (1:2)
CAS No.	2043778-87-4
Molecular Formula	C5H10D3Cl2N2
Molecular Weight	177.10 g/mol
Synonyms	1-(Methyl-d3)piperazine Dihydrochloride; (Methyl-d3)piperazine Hydrochloride; Piperazine-1-(methyl-d3) Dihydrochloride; N-Methyl-d3-piperazine Dihydrochloride; Deuterated N-Methylpiperazine Dihydrochloride; N-(Trideuteriomethyl)piperazine Dihydrochloride; 1-(Trideuteriomethyl)piperazine Dihydrochloride
EINECS	Contact for details

Quality Control

Our Piperazine, 1-(Methyl-D3)-, Hydrochloride (1:2) is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment (D%, atom %), and impurity profiles. We adhere to cGMP principles where applicable to support regulatory filings in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D%, NMR)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.