Description

3,4-Dibromo-Mal-Peg4-T-Butyl Ester is a specialized bifunctional PEG linker featuring a reactive maleimide group and a protected carboxylic acid. This compound is engineered for high-value bioconjugation and pharmaceutical research, enabling the stable, site-specific attachment of biomolecules. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, antibody-drug conjugate (ADC) development, and advanced material science to create novel therapeutic agents and functionalized polymers.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing stable, cleavable linkers connecting cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Modification: For site-specific conjugation to cysteine residues via the maleimide group, facilitating labeling, PEGylation, or immobilization.
• Polymer and Dendrimer Synthesis: Serves as a functional building block for creating tailored PEG-based polymers with specific reactive handles.
• Diagnostic Reagent Development: Used in the synthesis of contrast agents or fluorescent probes for imaging and diagnostic assays.
• Drug Delivery System Fabrication: Incorporated into nanoparticles, liposomes, or micelles to enable targeted drug release mechanisms.
• Surface Functionalization: For modifying biosensor surfaces, chromatography media, or other substrates to introduce specific biorecognition elements.

Basic Information

Product Name	3,4-Dibromo-Mal-Peg4-T-Butyl Ester
CAS No.	2030168-38-6
Molecular Formula	C23H39Br2NO10
Molecular Weight	649.37 g/mol
Synonyms	1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12-tetraoxapentadecane-15-oic acid, 1,1-dimethylethyl ester, 3,4-dibromo-; 3,4-Dibromo-maleimide-PEG4-t-butyl ester; DBCO-PEG4-t-butyl ester (Note: Common but distinct; included for search relevance); t-Butyl 3,4-dibromomaleimide-PEG4-carboxylate; Bifunctional PEG linker, Mal-PEG4-tBu ester, dibromo; N-(t-Butoxycarbonyl-PEG4)-3,4-dibromomaleimide; 15-(t-Butoxy)-3,6,9,12-tetraoxa-15-oxopentadecyl 3,4-dibromo-1H-pyrrole-2,5-dione
EINECS	Contact for details

Quality Control

Our 3,4-Dibromo-Mal-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development under cGMP and ISO 9001 guidelines for research and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.