Description

(R)-Gna-C(Bz)-Phosphoramidite is a high-purity, chiral phosphoramidite building block essential for the automated synthesis of oligonucleotides. This compound matters for its critical role in introducing modified nucleosides into synthetic DNA and RNA strands, enabling advanced research and therapeutic development. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories working on antisense oligonucleotides, siRNA, aptamers, and other nucleic acid-based therapeutics.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key monomer for the automated, machine-assisted synthesis of DNA/RNA strands.
• Antisense Oligonucleotide (ASO) Development: For the production of therapeutic oligonucleotides designed to modulate gene expression.
• siRNA and miRNA Synthesis: Enabling the manufacture of short interfering RNA and microRNA for gene silencing applications.
• Aptamer Production: Used in the synthesis of nucleic acid aptamers for diagnostic and therapeutic targeting.
• Research-Grade Probe Synthesis: For creating labeled or modified oligonucleotide probes used in genomics and molecular biology.
• Phosphoramidite Chemistry Research: Serving as a specialized reagent in methodological studies of nucleic acid chemistry.

Basic Information

Product Name	(R)-Gna-C(Bz)-Phosphoramidite
CAS No.	2023779-58-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-GNA-C(Bz)-Phosphoramidite; 1-[(2R,4S,5R)-5-(Benzoyloxymethyl)-4-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]oxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione; GNA Phosphoramidite (Bz protected); (R)-Glycerol Nucleic Acid C(Bz) Phosphoramidite; GNA-C(Bz) Phosphoramidite; (2R,4S,5R)-4-((Bis(1-methylethyl)amino)(2-cyanoethoxy)phosphino)oxy-5-(((phenylcarbonyl)oxy)methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran; GNA monomer phosphoramidite
EINECS	Contact for details

Quality Control

Our (R)-Gna-C(Bz)-Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to industry best practices and can support development under cGMP guidelines for therapeutic applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the product should be handled under an inert atmosphere (argon or nitrogen) and sealed immediately after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC/LC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous acetonitrile, DCM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.