Description

tert-Butyl 3-(1-Aminocyclopropyl)-1H-Indole-1-Carboxylate is a high-value, protected indole derivative featuring a strategically positioned aminocyclopropyl group. This compound serves as a critical advanced pharmaceutical intermediate (API) for the synthesis of complex bioactive molecules. It is primarily utilized by research and development teams in the pharmaceutical and biotechnology sectors for drug discovery programs targeting neurological and oncological pathways. The CAS number for this compound is 2007908-87-2.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those with indole-based scaffolds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for central nervous system (CNS) and oncology targets.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Item	Detail
Product Name	tert-Butyl 3-(1-Aminocyclopropyl)-1H-Indole-1-Carboxylate
CAS No.	2007908-87-2
Molecular Formula	C16H20N2O2
Molecular Weight	272.34 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 3-(1-aminocyclopropyl)-, 1,1-dimethylethyl ester; 3-(1-Aminocyclopropyl)-1H-indole-1-carboxylic acid tert-butyl ester; Boc-protected 3-(1-aminocyclopropyl)indole; tert-Butyl 3-(1-aminocyclopropyl)indole-1-carboxylate; 1-Boc-3-(1-aminocyclopropyl)indole; 2007908-87-2; (1-(1-(tert-Butoxycarbonyl)-1H-indol-3-yl)cyclopropan-1-amine)
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(1-Aminocyclopropyl)-1H-Indole-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and MS. Our quality system is designed to support both non-GMP and GMP-grade requests, ensuring reliable supply for critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.