Description

4-(Trifluoromethyl)-1H-Indol-6-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its indole core and trifluoromethyl substituent. This compound is of significant commercial importance due to its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for drug discovery and process development programs.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drugs targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides, leveraging the trifluoromethyl group's influence on biological activity.
• Fluorinated Compound Library Synthesis: Serves as a valuable scaffold for creating diverse fluorinated compound libraries for high-throughput screening in drug discovery.
• Material Science Precursor: Potential use in the development of organic electronic materials and functional dyes due to its electron-deficient aromatic system.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.

Basic Information

Product Name	4-(Trifluoromethyl)-1H-Indol-6-Amine
CAS No.	2007908-69-0
Molecular Formula	C9H7F3N2
Molecular Weight	200.16 g/mol
Synonyms	6-Amino-4-(trifluoromethyl)-1H-indole; 4-(Trifluoromethyl)-6-aminoindole; 1H-Indol-6-amine, 4-(trifluoromethyl)-; 4-Trifluoromethyl-1H-indol-6-ylamine; 4-CF3-1H-indol-6-amine
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-1H-Indol-6-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.