Description

4-(5-Bromo-1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)Butanoic Acid is a high-purity, functionalized isoindoline-1,3-dione derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific brominated phthalimide functionalities into target structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting neurological disorders and oncology.
• Proteolysis-Targeting Chimera (PROTAC) Linker: Used in the design and construction of bifunctional PROTAC molecules for targeted protein degradation.
• Agrochemical Synthesis: Serves as an intermediate for developing new generation herbicides and fungicides with enhanced efficacy.
• Polymer Modification: Employed to introduce functional groups into polymer backbones, modifying properties like solubility, adhesion, and thermal stability.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Bioconjugation: Acts as a handle for attaching payloads to antibodies, proteins, or other biomolecules in ADC (Antibody-Drug Conjugate) and diagnostic probe development.
• Material Science Research: A building block for creating organic semiconductors, dyes, and pigments with specific electronic properties.

Basic Information

Product Name	4-(5-Bromo-1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)Butanoic Acid
CAS No.	299964-12-8
Molecular Formula	C12H10BrNO4
Molecular Weight	312.12 g/mol
Synonyms	5-Bromo-2-(3-carboxypropyl)isoindoline-1,3-dione; 4-(5-Bromophthalimido)butyric Acid; 5-Bromo-N-(3-carboxypropyl)phthalimide; 2-(5-Bromo-1,3-dioxoisoindolin-2-yl)butanoic acid; 5-Bromophthalimidobutyric Acid; γ-(5-Bromophthalimido)butyric Acid; Butanoic acid, 4-(5-bromo-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
EINECS	Contact for details

Quality Control

Our production of 4-(5-Bromo-1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)Butanoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical R&D and scale-up processes. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We operate under a quality system aligned with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.