Description

Ethyl (E)-2-(3-(3-Nitrophenyl)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate is a high-purity, advanced pharmaceutical intermediate of significant interest in modern organic synthesis. This compound matters for its role as a key building block in the development of novel therapeutic agents, particularly within medicinal chemistry research. It is primarily needed by R&D laboratories and pharmaceutical manufacturers focused on synthesizing complex heterocyclic molecules for drug discovery programs targeting various disease pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those with tetrahydrobenzo[b]thiophene and acrylamide scaffolds.
• Medicinal Chemistry Research: Used as a building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Organic Synthesis Reference Standard: Employed as a high-purity standard for analytical method development and validation in QC laboratories.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological targets and pathways.
• Academic & Institutional R&D: A key reagent for universities and research institutes exploring new synthetic methodologies and heterocyclic chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	Ethyl (E)-2-(3-(3-Nitrophenyl)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
CAS No.	299953-31-4
Molecular Formula	C22H22N2O5S
Molecular Weight	426.49 g/mol
Synonyms	Ethyl (2E)-2-[[(2E)-3-(3-nitrophenyl)-2-propenoyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid, 2-[(1E)-3-(3-nitrophenyl)-1-propen-1-ylamino]-, ethyl ester; (E)-Ethyl 2-(3-(3-nitrophenyl)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate; 299953-31-4; Ethyl 2-[(E)-3-(3-nitrophenyl)prop-2-enamido]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl (E)-2-(3-(3-Nitrophenyl)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.