Description

1H-Indole, 1-(Cyclopropylcarbonyl)-2,3-Dihydro- is a high-purity, advanced pharmaceutical intermediate characterized by its unique indole core functionalized with a cyclopropanecarbonyl group. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates targeting specific biological pathways.
• Organic Synthesis Building Block: Used in research and development for constructing novel heterocyclic compounds and exploring structure-activity relationships (SAR).
• Medicinal Chemistry Research: Serves as a scaffold for the discovery and optimization of new chemical entities with potential therapeutic value.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials.
• Agrochemical Research: Potential application as an intermediate in the development of new crop protection agents with novel modes of action.

Basic Information

Product Name	1H-Indole, 1-(Cyclopropylcarbonyl)-2,3-Dihydro-
CAS No.	293324-65-9
Molecular Formula	C12H11NO
Molecular Weight	185.22 g/mol
Synonyms	1-(Cyclopropylcarbonyl)-2,3-dihydro-1H-indole; 2,3-Dihydro-1-(cyclopropylcarbonyl)-1H-indole; 1H-Indole-1-carboxylic acid, 2,3-dihydro-, cyclopropyl ester; 1-(Cyclopropanecarbonyl)indoline; Indoline-1-carboxylic acid cyclopropyl ester
EINECS	Contact for details

Quality Control

Our production of 1H-Indole, 1-(Cyclopropylcarbonyl)-2,3-Dihydro- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is manufactured in a controlled environment suitable for pharmaceutical intermediates. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as assay, identity, and impurity profiles. We support our clients' regulatory needs and can supply material suitable for use under cGMP guidelines for non-sterile intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.