Description

(R)-1-Iodo-2-(Boc-Amino)-3-Methylbutane CAS NO 293305-70-1 is a high-purity chiral building block featuring a protected amino group and a reactive iodo handle. This compound is critically important for the stereoselective synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing peptidomimetics and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of protease inhibitors, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Peptidomimetic Synthesis: Used to introduce non-natural, branched-chain amino acid analogs into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as an electrophilic alkylating agent in stereocontrolled carbon-carbon and carbon-heteroatom bond-forming reactions.
• Agrochemical Research: Building block for creating chiral active ingredients with specific biological activity.
• Ligand and Catalyst Development: Precursor for synthesizing chiral ligands and organocatalysts used in asymmetric catalysis.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules due to its reactive iodine atom and protected amine.

Basic Information

Product Name	(R)-1-Iodo-2-(Boc-Amino)-3-Methylbutane
CAS No.	293305-70-1
Molecular Formula	C₁₀H₂₀INO₂
Molecular Weight	313.18 g/mol
Synonyms	(R)-1-Iodo-2-((tert-Butoxycarbonyl)amino)-3-methylbutane; (R)-N-Boc-2-Amino-3-methyl-1-iodobutane; (R)-2-(Boc-Amino)-3-methyl-1-iodobutane; (R)-1-Iodo-2-(tert-butoxycarbonylamino)-3-methylbutane; tert-Butyl (R)-(1-iodo-3-methylbutan-2-yl)carbamate; (R)-Boc-Val-Iodide; (R)-BocNH-Val-I; (R)-N-Boc-3-methyl-2-aminobutyl iodide
EINECS	Contact for details

Quality Control

Our (R)-1-Iodo-2-(Boc-Amino)-3-Methylbutane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and decomposition. Allow the container to reach room temperature before opening to prevent moisture condensation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.