Description

Maleimidopropionic Acid Hydrazide Hydrochloride is a high-purity, heterobifunctional crosslinking reagent featuring a maleimide group and a hydrazide moiety. This compound is critically important for the site-specific conjugation of biomolecules, enabling the creation of stable, well-defined bioconjugates for advanced research and development. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic assay formulation.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Used to covalently attach cytotoxic payloads to monoclonal antibodies via the hydrazide group, forming acid-labile hydrazone bonds for targeted drug delivery.
• Protein and Peptide Labeling: Enables the site-specific modification of cysteine residues (via maleimide) with tags, fluorophores, or other functional molecules for imaging and detection studies.
• Diagnostic Reagent Synthesis: Employed in the development of enzyme-linked immunosorbent assay (ELISA) kits and other immunoassays by conjugating enzymes or other reporter molecules to antibodies or antigens.
• Surface Functionalization: Used to modify nanoparticles, biosensors, or solid supports with bioactive ligands for capture and detection applications.
• Biomaterial Crosslinking: Facilitates the crosslinking of hydrogels or polymer scaffolds with incorporated peptides or proteins for tissue engineering and controlled release systems.
• Stable Bioconjugate Research: Serves as a key reagent in academic and industrial R&D for exploring novel therapeutic and diagnostic bioconjugate platforms.

Basic Information

Product Name	Maleimidopropionic Acid Hydrazide Hydrochloride
CAS No.	293298-33-6
Molecular Formula	C7H10N3O3 • HCl
Molecular Weight	221.63 g/mol (Free base: 184.17)
Synonyms	3-Maleimidopropionic Acid Hydrazide Hydrochloride; 3-Maleimidopropionic Hydrazide Hydrochloride; Maleimidopropionic Hydrazide HCl; MPH-HCl; β-Maleimidopropionic Acid Hydrazide Hydrochloride; N-(3-Hydrazinyl-3-oxopropyl)maleimide Hydrochloride; 1-[3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)propanoyl]hydrazine Hydrochloride
EINECS	Contact for details

Quality Control

Our Maleimidopropionic Acid Hydrazide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 90.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMF, DMSO; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.