Description

5-(4-Fluorobenzyl)-2,4-Thiazolidinedione is a high-purity pharmaceutical intermediate and research chemical of significant interest in medicinal chemistry. This compound matters as a key synthetic precursor and structural motif in the development of novel therapeutic agents, particularly those targeting metabolic disorders. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of advanced drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of thiazolidinedione-based drug candidates, a class known for their activity as PPARγ agonists.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies aimed at developing new treatments for type 2 diabetes and related metabolic syndromes.
• Biochemical Tool Compound: Employed in in vitro and in vivo research to study insulin sensitization pathways and adipocyte differentiation.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for the identification and quantification of related active pharmaceutical ingredients (APIs).
• Fine Chemical Synthesis: Acts as a specialized reagent for the introduction of the fluorobenzyl-thiazolidinedione moiety into more complex molecular architectures.

Basic Information

Product Name	5-(4-Fluorobenzyl)-2,4-Thiazolidinedione
CAS No.	291536-42-0
Molecular Formula	C10H8FNO2S
Molecular Weight	225.24 g/mol
Synonyms	5-[(4-Fluorophenyl)methyl]-2,4-thiazolidinedione; 5-(4-Fluorobenzyl)thiazolidine-2,4-dione; 4-Fluorobenzylthiazolidinedione; TZD Fluorobenzyl Derivative; 291536-42-0; 5-(p-Fluorobenzyl)-2,4-thiazolidinedione; 2,4-Thiazolidinedione, 5-[(4-fluorophenyl)methyl]-
EINECS	Contact for details

Quality Control

Our 5-(4-Fluorobenzyl)-2,4-Thiazolidinedione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is moisture-sensitive (hygroscopic) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.