Description

1-Boc-3-Iodoindazole is a high-value, protected heterocyclic building block essential for modern synthetic organic chemistry. This compound is specifically designed for the controlled introduction of the indazole scaffold into complex molecular architectures, enabling the synthesis of novel active pharmaceutical ingredients (APIs) and advanced materials. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require precise and reliable synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule drug candidates, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators containing the indazole moiety.
• Material Science: Serves as a building block for creating functional organic materials, such as ligands for catalysts or components in organic electronics.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) to form carbon-carbon bonds.
• Medicinal Chemistry SAR Studies: Facilitates structure-activity relationship (SAR) exploration by allowing modular functionalization at the 3-position of the indazole ring.
• Peptidomimetics & Bio-conjugation: The Boc-protected amine allows for further deprotection and derivatization, useful in designing peptide mimics and bioconjugation linkers.

Basic Information

Product Name	1-Boc-3-Iodoindazole
CAS No.	290368-00-2
Molecular Formula	C₁₂H₁₃IN₂O₂
Molecular Weight	344.15 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-iodo-1H-indazole; 3-Iodo-1H-indazole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 3-iodo-1H-indazole-1-carboxylate; 3-Iodo-1-Boc-indazole; 1-Boc-3-iodoindazole; 1-N-Boc-3-iodoindazole; Boc-3-I-indazole; 290368-00-2
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Iodoindazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.