Description

3-Indolizinecarbonitrile,Octahydro-,(3R,8Ar)-Rel-(9Ci) is a chiral, octahydro-indolizine derivative, a sophisticated chemical building block of significant interest in advanced organic synthesis. Its value lies in its stereochemically defined, rigid bicyclic framework and the versatile nitrile functional group, enabling precise molecular construction. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold for the development of new therapeutic agents, particularly in central nervous system (CNS) and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel, stereospecific pesticides and herbicides where the specific spatial orientation of the molecule is critical for bioactivity.
• Asymmetric Catalysis Ligand Precursor: The chiral indolizine structure can be elaborated to create novel ligands for asymmetric hydrogenation and other catalytic transformations.
• Natural Product & Alkaloid Analog Synthesis: Acts as a core structural motif for constructing complex alkaloid analogs and other natural product-like compounds for biological screening.
• Advanced Material Research: Investigated as a monomer or precursor for specialty polymers and functional materials with specific optical or electronic properties.

Basic Information

Product Name	3-Indolizinecarbonitrile,Octahydro-,(3R,8Ar)-Rel-(9Ci)
CAS No.	289882-35-5
Molecular Formula	C9H14N2
Molecular Weight	150.22 g/mol
Synonyms	(3R,8aR)-Octahydroindolizine-3-carbonitrile; rel-(3R,8aR)-Octahydroindolizine-3-carbonitrile; (3R,8aR)-Octahydro-1H-indolizine-3-carbonitrile; 1H-Indolizine-3-carbonitrile, octahydro-, (3R,8aR)-rel-; Octahydroindolizine-3-carbonitrile (stereoisomer); Bicyclic nitrile intermediate; Chiral indolizine nitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Indolizinecarbonitrile,Octahydro-,(3R,8Ar)-Rel-(9Ci) is produced and analyzed under strict quality management protocols to ensure identity, purity, and enantiomeric excess meet the exacting standards required for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) providing comprehensive analytical data, including chiral purity by HPLC, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.